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Duration and Dosing in Oncology Standard treatment duration is 5 years , though some cases extend to 10 years based on recurrence risk Typical dose: 20 mg/day , taken orally Extended therapy is associated with better long-term survival but increases cumulative risk of uterine complications and venous thromboembolism Summary of Clinical Impact in Women Reduces recurrence of ER+ breast cancer by up to 50% Reduces risk of contralateral breast cancer (in the opposite breast) Improves long-term survival, especially when started early after surgery Offers preventive benefits in genetically predisposed women Requires monitoring for endometrial health and clotting risk Step-by-Step: Tamoxifen’s Mechanism of Action in Men (Off-Label Use) 1