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[67] Additionally, hCDR1 improved cognitive behavior and brain pathology in lupus mice [68] and downregulated the expression of the indoleamine 2, 3-dioxygenase (IDO) gene, which is increased in SLE patients

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In the control group, saline (0.3 cc, 0.9%) was administered intraperitoneally 45 min post-midline laparotomy, which was the sole surgical intervention