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The requirement of aspartate for maximum glutamate synthesis indicates that glutamate synthesis from α-ketoglutarate probably occurs by transamination, and pathway models for interaction between biosynthesis and oxidative degradation of both glutamate and GABA suggest that transamination may also be the default reaction for initiation of glutamate oxidation

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Accordingly, we found that in vitro activation and the costimulatory potential of GSH-deficient FoB was decreased compared to control cells upon 24h stimulation as indicated by lower expression of CD25, CD69, GL-7 and CD80/CD86 (Supplementary Fig

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