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History Initial investigations into the role of NO were conducted showing that nitrogen-containing compounds such as sodium azide (NaN 3 ), sodium nitrite (NaNO 2 ), hydroxylamine (NH 2 OH), nitroglycerin (C 3 H 5 N 3 O 9 ), and sodium nitroprusside (Na 2 [Fe(CN) 5 NO]) were able to activate GC [3, 19–23] (Figure 2)

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Additionally, supplementation of taurine has been shown to increase glutathione in the lens and ameliorate cataracts in animal models [60]