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Interactions Among Endocrine Axes The activity of the insulin-GH-IGF-axis is dependent on the other endocrine axes which have permissive actions on GH stimulated IGF-I expression and affect IGFBPs and proteases (Figure 4)

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We chose to measure these levels in immune cells given the essential role that the immune system has in the aging process, being both a modulator and an accurate marker of the aging rate of an individual [1,22,23]