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How peptide immunotherapy achieves tolerance The mechanisms include induction of specific T-cell anergy (functional inactivation of allergen-reactive T-cells), differentiation of naive T-cells into regulatory T-cells, immune deviation (shifting the Th2/Th1 ratio toward Th1), and allergen-specific Th2 cell deletion

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doi: 10.1126/scitranslmed.adk3295 35 ProalADVanElzakkerMBAlemanSBachKBoribongBPBuggertMet al