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GABRA-2 Gene Variants CYP2C19 poor metabolisers change valium detox by extending dose reduction schedules to around 20 – 40 weeks from 12 weeks due to [2]: A 40% reduction of oral clearance (CL/F) compared to normal metabolisers, a 5 – 10% reduction every 2 – 4 weeks rather than 1 – 2 weeks may be required [2] [31] An increased valium elimination half-life compared to normal metabolisers (92 vs 56 hours)

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