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Metformin-induced B12 deficiency: Easily overlooked but easily treated | New Zealand Doctor

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Current and recent areas of preclinical investigation include: Tendon and ligament repair models — examining fibroblast response and collagen synthesis following induced tendon injury Gastrointestinal mucosal repair — BPC-157’s gastric origin makes it particularly relevant to GI research, with studies examining gastric ulcer models, intestinal anastomosis healing, and inflammatory bowel disease models Muscle repair and regeneration — preclinical studies in crush injury and laceration models Bone healing — studies examining bone defect repair in animal models Neurological research — examination of dopaminergic and serotonergic system interactions, as well as studies involving traumatic brain injury models Vascular biology — angiogenesis mechanisms and endothelial function studies Wound healing — skin and soft tissue repair across multiple injury models Across virtually all of these contexts, a consistent theme in the literature is BPC-157’s apparent ability to accelerate or enhance the repair process in injured tissue — though it’s important to note that nearly all existing data comes from in-vitro or animal studies, and human clinical data remains limited