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12,26 Furthermore, the formation of NAPQI adducts contributes to oxidative stress, mitochondrial dysfunction, disrupted Ca 2+ homeostasis, necrotic cell death, centrilobular necrosis, and eventual liver failure (Figs

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Elevated proinflammatory factors, including IL-6, TNF-α, and matrix metalloproteinase (MMP)-9, have been detected in KC tears, with higher levels correlating with increased KC severity [84]