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Conditions Commonly Caused by B12 Deficiencies B12 deficiencies are common and can cause a wide range of symptoms and health issues, including: Depression Fatigue, including chronic fatigue Poor concentration and memory Insomnia and other sleep disorders Headaches Heart disease Anemia Digestive disorders, including irritable bowel syndrome (IBS) Peripheral neuropathy Nearly anyone can suffer from a B12 deficiency

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The overexpression of Parkin in cortical neurons has been demonstrated to increase the levels of PGC-1α and mtDNA copy number (Zheng et al., 2017)