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Therefore, the GPX4/GSH and FSP1/CoQ10 systems collectively constitute an endogenous “dual-safeguard” mechanism for cellular defense against ferroptosis

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The mbpa gene encodes myelin basic protein (MBP), a critical structural component of the myelin sheath that facilitates tight compaction of myelin layers and ensures efficient nerve impulse conduction ( mpz gene encodes myelin protein zero, a major transmembrane glycoprotein essential for the formation and maintenance of myelin in the peripheral nervous system, contributing to membrane adhesion and structural stability ( tnf-α , il-6 , il-1β , crp5 ), while also suppressing ROS accumulation

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