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The MIPS payment adjustment factors specified for a year must result in differential payments such that MIPS eligible clinicians with final scores above the performance threshold receive a positive MIPS payment adjustment factor, those with final scores at the performance threshold receive a neutral MIPS payment adjustment factor, and those with final scores below the performance threshold receive a negative MIPS payment adjustment factor

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Leveraging integrated omics, CRISPR-based perturbation screens, and drug discovery platforms in physiologically relevant models will be essential for identifying when and how modulation of this circuit can be harnessed to enhance T cell–based immunotherapies for solid tumors