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In HK-2 cells, the MGAT5 inhibitor glucosamine hydrochloride reduces LOXL2 secretion by inhibiting its N-glycosylation, thereby attenuating TGF-β1-induced fibrosis (Kamiya et al., 2023)

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2D models offer a cost-effective, high-throughput means of mechanistic screening, while 3D models offer the physiological relevance, spatial architecture, and mechanical cues necessary to recapitulate the altered tissue microenvironment of lipedema