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Metformin attenuated the progression of OA in an MIA-induced mouse model To further investigate the effect of metformin on OA progression, radiological assessments, histological analyses and plasma assays were conducted to evaluate subchondral bone remodeling, articular cartilage degradation, and inflammation at 8 weeks post-MIA injection

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Flexor tendon nodule: A nodule can develop on the surface of the flexor tendon of the wrist, making it difficult to straighten the “trigger finger” and causing a popping or catching sensation