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UC-associated metabolic conditions, such as glucose depletion 19 and cystine accumulation 20 , create an environment conducive to disulfidptosis, implicating it in disease progression

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In this line, the authors of one of the first studies on programmed erythrocyte death demonstrated that erythrocytes from patients with different forms of anemia (sickle cell anemia, thalassemia, and G6PDdeficiency) are more susceptible toward oxidative stress as compared with erythrocytes from healthy volunteers