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Additionally, the demethylase inhibitor GSK-J4 prevents H3K27 demethylation by targeting KDM6A, downregulating DKK1 and TGF-β1, and alleviating fibrosis in DN (Hung et al., 2022)

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By integrating multi-omics analysis, machine learning, big data analytics, and remote monitoring technologies, caregivers can provide more precise, personalized, and continuous care services, significantly improving the management of CVDs and patients' quality of life