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2.4 Charting the data Following initial screening, two reviewers (MWS, AT) extracted three specific components using a standardized form: (i) key elements of the antioxidant supplements, (ii) the most frequently reported outcome measures used to assess therapeutic controversies, and (iii) data evaluating safety and effectiveness of the supplements

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Several small-molecule compounds (e.g., RSL3, ML162, ML210, FIN56 and FINO 2 ) can directly or indirectly inhibit GPX4 activity (Fig