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Ascorbic acid is critical and essential in the maintenance and repair of joints and joint cartilage, proteoglycans and other joint components, synthesis of collagen, tooth, bone, skin and blood vessel maintenance and also in the healing and repair of burns, wounds and fractures

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[2] Causes are usually related to conditions that give rise to malabsorption of vitamin B 12 , particularly autoimmune gastritis in pernicious anemia