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In turn, the same haplotype in the Han Chinese ethnic group, constitutes a high-risk factor for the occurrence, with the use of allopurinol, of other reactions such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and DRESS syndrome.11 Thus, the same HLA alleles can cause different adverse reactions with the same medication, in different ethnicities, or with different medications, in the same population (Table 2)

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This review does not include proteomic applications for plasma and body fluid analysis for the discovery of biomarkers or proteomic applications within epidemiology and population sciences