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Conversely, other drugs, such as trabectedin, reduce the number of macrophages in the TME, thus limiting their pro-tumoural effects

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In some embodiments, NNMT inhibitors may be used with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels, to produce synergistic or additive effects to provide muscular therapy