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As a central regulatory process governing cellular metabolism and homeostasis, the activation of autophagy is closely associated with functional polarization, survival, and pro-tumor activity of macrophages [59–61]

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The clustering of non-templated changes with regions of templated switches, which were particularly biased to the 5’ end of the templated regions, led the authors to speculate that error-prone repairs may participate in the changes at the vlsE locus (Verhey et al., 2018b)