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Reducing the Burden – Genetic Counseling Since thalassemia is not sex-linked and affects only individuals homozygous for the trait, and carriers are asymptomatic, the World Health Organization (WHO) recommends screening and genetic counseling to be included as part of healthcare systems management of hemoglobinopathies including thalassemia, with a view to reduce the number of new patients born in countries with high incidence of the disease

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MTHFR variants affect folate metabolism, which interconnects with B12-dependent methylation