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Fibrogenesis results from extracellular signaling from injured hepatocytes, liver sinusoidal endothelial cells, activated Kupffer cells, T cells, B cells, and natural killer cells, promoting hepatic stellate cells (HSCs) activation

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The evidence has been largely RNA- and protein-based with increased concentrations of interleukin (IL)-4, tumor necrosis factor (TNF)- α , soluble TNF receptor 1 (sTNFR1), and soluble IL-2 receptor consistently reported in BD compared to healthy controls [67, 68]