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These include (but aren’t limited to): Age Genetics Excessive sugar intake5 Long-term nonsteroidal anti-inflammatory drug (NSAID) use6 Excessive alcohol use7 Vitamin D deficiency8 Chronic inflammation9 Yeast ( Candida ) overgrowth10 Starvation11 Parenteral feeding12 (i.e., nutrition via intravenous solution) Bodily trauma13 Emotional stress14 Infection15 Chemotherapy16 Radiation17 A leaky gut could also indicate more complex health concerns, such as: Food allergies18 Celiac disease19 Ulcerative colitis and Crohn’s disease20 Irritable bowel syndrome (IBS)21 Inflammatory bowel disease (IBD)22 Metabolic diseases23 Nonalcoholic fatty liver disease24 Diabetes25 Sepsis26 Despite some claims, leaky gut doesn’t appear to be related to autism, depression, anxiety, or skin problems like eczema