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The above procedure was repeated with inhibitor concentrations spanning 0.3 – 60 µM to determine the effective concentration (EC 50 ) required to inhibit 50% NNMT activity in cultured adipocytes

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After oral dosing at 30 mg/kg, the terminal half-life was 14.8 hours but the peak was only 14.5 ng/mL, giving oral bioavailability of 3.5%