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Our experimental studies (28) on rats with application of 125I-melatonin tracer, administered into the arterial circulation of the gut (celiac artery) in fasted rats, to detect the melatonin binding sites in GIT, revealed that the highest level of labeled tracer measured 15 min following its administration was found in all digestive organs, particularly in the liver, and less in the gastric and small intestinal mucosa (duodenum, jejunum and ileum) and colon

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It also faces certain development challenges, showing an overall trend of coexisting potential and opportunities, which can be summarized in the following aspects