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In fulfilling this protective role, reduced glutathione is converted into oxidized glutathione, at which point it becomes inactive

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In adults, single doses above 10 grams or 150 mg/kg have a reasonable likelihood of causing toxicity.[34] Toxicity can also occur when multiple smaller doses within 24 hours exceeds these levels, or even with chronic ingestion of doses as low as 4 g/day, and death with as little as 6 g/day