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Pernicious Anemia Complications If you don't get treatment for pernicious anemia, you could face the following complications: Higher risk of gastric cancer Fractures in the back, upper leg, and upper forearm Brain and nervous system problems that could become permanent A false-positive Pap smear because a B12 deficiency affects the way certain cells in the cervix look Takeaways Pernicious anemia (PA) is an autoimmune condition where your body can’t absorb vitamin B12 and so can't make enough healthy red blood cells