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For example, the sarcoplasmic reticulum/endoplasmic reticulum-associated calcium efflux pump SERCA, which regulates intracellular calcium concentration by mediating uptake of calcium into endoplasmic reticulum stores, becomes activated when its critical Cys (Cys674) is oxidized to S-nitrosocysteine or Cys sulfenic acid, then to the mixed disulfide with glutathione [116, 117]

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5-fluorouracil enhances the antitumor activity of the glutaminase inhibitor cb-839 against pik3ca-mutant colorectal cancers