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Additionally, selecting states would greatly reduce the number of independent geographic areas subject to selection under the model, and thus would decrease the statistical power of the model evaluation

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Most interestingly, when we calculated the plasma levels of LH, FSH and TSH using a low reference range as represented in Table 4 and as such, we surprisingly found only a small percentage of patients had comorbid anterior pituitary hormone deficiencies (between the range 84–100 µ/l of IGF-1 plasma levels: low LH=4.2%