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both high-dose glycine and D-serine, a full agonist for the glycine-binding site on NMDA receptors, have been reported to aid control of negative symptoms.87,88 GLYCINE AS A SUPPLEMENTAL NUTRIENT Clinical studies of supplemental glycine that have achieved interesting results have used daily glycine doses ranging from 3 g to as high as 0.8 g/kg, split into 2-4 servings.45,46,85,89 These studies have failed to note any significant side effects, presumably reflecting the fact that glycine is efficiently absorbed and hence does not cause diarrhea.45,46,85,89 Ample doses of glycine are not impractical because glycine is inexpensive, has a mildly sweet flavor, is highly and rapidly soluble, and can be added to a wide range of beverages