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The effectiveness of the KD was assessed in two transgenic mouse models: Tg4510 mice (tauopathy model) and APP/PS1 mice (amyloidosis model)

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As we highlighted above with recombinant mAbs, and as shown in historical dengue virus mother–infant data, the theoretical risk of ADE in CP prophylaxis is highest in the weeks following transfusion, when antibody serum neutralization titres fall to sub-protective levels