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Its popularity in many fields is largely owed to a very short generation time, a relatively large number of offspring, ease of genetic manipulation compared to other model organisms such as mice, and a high degree of mechanistic conservation with other organisms, including mammals 67

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351 IRF7 deficiency Genetic studies have demonstrated that loss-of-function mutations in IRF7 abolish type I and III IFN amplification, predisposing affected individuals to life-threatening influenza infection