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Collagen synthesis was significantly increased for both soluble factor pairings compared to the control over the course of the 7-day experiment but the IGF-1/GDF-5 pairing induced a significantly greater amount of soluble collagen synthesis than pairing with IGF-1/bFGF, combinations with PDGF-BB instead of IGF-1 and non-supplemented control

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Addressing the problem while tissue retains regenerative capacity offers better outcomes than waiting until degeneration becomes established