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Both agonists were found to potentiate the cellular actions of HGF

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The latter, in turn, massively produce and release pro-inflammatory cytokines, leading to an inflammatory cycle that exacerbates adipose tissue inflammation and triggers a systemic inflammatory cascade through immune cell infiltration of other insulin-dependent tissues ( In this regard, the dual function exhibited by leptin, namely as hormone and cytokine, is paradigmatic of the close and evolutionary conserved tie between the metabolic and immune system