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Vitamin B1 is an exogenous antioxidant with the ability to scavenge the free radicals HO ● and HOO ● [45]

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Additionally, oxaliplatin antagonized voltage-operated K + channels on the peripheral myelinated nerve fibers with a similar pattern of action to that of 4-aminopyridine (a classical antagonist of voltage-operated K + channels) (Kagiava et al., 2008)