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SCFAs that are absorbed into the circulation, especially acetate and propionate, are oxidized in the liver and skeletal muscle and may play a role in appetite regulation (7, 36, 37)

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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week — but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

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