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A four-week clinical trial of sulforaphane in COPD patients failed to increase antioxidant gene targets of Nrf2 (such as HO-1) or to reduce oxidative stress and inflammation [123]

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5.3 T cell activation by co-stimulatory signals In addition to cytokine and chemokine-mediated regulation, the innate immune system provides essential co-stimulatory signals for T cell activation