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However, the individual studies compiled into the meta-analysis reported widely differing outcomes, which may reflect the specific populations they were studying

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FSP1 (encoded by the AIFM2 gene), a NAD(P)H-dependent ubiquinone oxidoreductase, is a major means of ferroptosis control, acting independently of GPX4 by catalysing the reduction of ubiquinone to its hydroquinone form, ubiquinol, consuming NAD(P)H 4,5