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Phosphodiesterase type 5 (PDE5) inhibitors are medications used to treat erectile dysfunction (ED) and pulmonary hypertension. They include sildenafil, vardenafil, tadalafil, and avanafil. These medications inhibit the PDE5 enzyme in endothelial cells

Most commonly these formulas include a blend of methionine, inositol, choline and Vitamin B12

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Filzmoser, P., Liebmann, B

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