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Some practitioners recommend cycling NAC, such as 5 days on and 2 days off, to prevent tolerance, though this is not well-studied

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Instead, laboratory studies show it interacts with skin cells in a few specific ways: Stimulates fibroblasts to produce collagen and glycosaminoglycans, key building blocks of skin structure Increases MMP-2 activity , an enzyme involved in remodeling damaged tissue Reduces pro-inflammatory signaling , including cytokines like TNF-α and IL-6 in experimental models Supports antioxidant activity , helping offset oxidative stress in damaged tissue These are real, published mechanisms, but they describe tissue repair , not acne treatment