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Stress-induced oxidation of nuclei is crucially important for the regulation of gene expression and as associated signal transduction pathways, as well as the control of nuclear thiol–disulfide redox states by nucleoredoxins, GRXs, and TRX1 (Kneeshaw et al

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The imported cystine is reduced to cysteine via the glutathione (GSH) or thioredoxin reductase 1 (TXNRD1)-dependent cystine reduction pathway (Ren et al., 2017)