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In line with this view, a metabolic shift toward FAO and ketogenesis was observed in the skeletal muscle of ALS patients 17 and a genetic mouse model 4 , and UCP2 expression itself was shown to depend upon the activation of fatty acid metabolism 18

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Establishment of PDXOS model and therapeutic effect evaluation The osteosarcoma patient-derived xenograft animal model (PDX) was established in female BALB/c nude mice