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These findings suggest that LMWF has significant therapeutic potential in inhibiting human IPF by mitigating inflammation and EMT processes (Wu et al., 2021)

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Epigenetic modifications, including hypomethylation of ERβ and aromatase promoters, further sustain this estrogen-driven phenotype, with endocrine-disrupting chemicals (EDCs) such as dioxins and phthalates potentially exacerbating these epigenetic alterations ( Progesterone resistance, characterized by impaired progesterone receptor (PR) signaling despite bioavailable progesterone, perpetuates ectopic lesion survival and contributes to infertility ( The interplay of estrogen dominance and progesterone resistance disrupts endometrial homeostasis, directly impacting fertility