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Leukocytes enhance inflammatory and catabolic degenerative changes in the intervertebral disc after endplate fracture in vitro without infiltrating the disc

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The transcription factor Nrf2, possibly in complexes with other Jun or Maf proteins, was found to be responsible for trans -activating the human GCLC promoter via binding to ARE4 in response to numerous treatments including β-NF, pyrrolidine dithiocarbamate, TBH [104,105], and insulin [106]