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Third, GSNO interacts with E3 ubiquitin ligase C-terminus Hsc70 interacting protein (CHIP), inhibiting CHIP-CFTR interaction and reducing CFTR ubiquitination, which increases both mature and immature F508del-CFTR levels and enhances cell surface expression (Zaman et al., 2019)

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Unlike established metabolic therapies, AOD-9604 lacks published peer-reviewed data demonstrating clinical efficacy in human populations [3]