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Frontiers | Beyond glycemic control: the cardiac and hepatic benefits of SGLT2 and DPP-4 inhibitors in mitigating chronic cadmium-induced inflammation, oxidative/nitrative stress, apoptosis and fibrosis

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Their distinguishing characteristics compared to the native peptide include modifications at positions 26 and 34, where lysine is conjugated to a lipid chain or substituted by arginine, and at position 8 in semaglutide, where an Aib is incorporated to enhance stability against DPP-4 degradation

to use fat as fuel instead of storing it