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Since ROS regulate the mitogen-activated protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3 K) [36], it is very likely that excessive intracellular ROS scavenging after exposure to drug/s with high antioxidant potential (alone or in combinations) may disrupt the cellular redox homeostasis and, thus, proliferation and survival-related signaling pathways

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D., “When Acetaminophen Use Becomes Toxic

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