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This, in turn, results in sleep deprivation and additional stress for patients with AD (105, 106)

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Proc Natl Acad Sci U S A (1999) 96(5):2071–6.10.1073/pnas.96.5.2071 129 KamuraTSatoSHaqueDLiuLKaelinWGJrConawayRCet alThe Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families