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With this treatment, the lesions improved progressively, with desquamation, until their almost complete disappearance within a week, leaving minimal residual pigmentation

nacetyl cystine

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One of ADCs in clinic containing this linker is Loncastuximab tesirine which also contains a pegylated spacer to balance the lipophilicity of the payload from PDB dimer family, SG3199 (Lee 2021)